Response to JAK inhibition suggests that interferon hyperactivation underlies psoriatic arthritis in Down Syndrome.

This study used mass cytometry to create a scientific ‘map’ of the immune system. Then, scientists compared the immune system maps of people with Down syndrome to those without and found that, on average, people with Down syndrome have dysregulation in every detected branch of their immune system…..

This project took a deep dive into the T cell biology of people with Down syndrome. T cells are an important cell in the immune system. There are numerous types and subtypes of T cells, each with specific functions in the immune response. For example, “cytotoxic T cells” kill dangerous cells infected by virus or from tumors…..

Individuals with Down syndrome have widespread immune dysregulation, including an increased risk of autoimmune and autoinflammatory skin conditions, like alopecia areata. The triplication of chromosome 21 causes activation of a branch of the immune system called interferon, known to contribute to autoimmunity…..