Should individuals with Down syndrome be considered high-risk during COVID-19? A review of the science and current evidence.

This “Perspective” outlines why individuals with Down Syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the typical euploid population, thus justifying additional monitoring and specialized care for this vulnerable population.